Search results for " White matter lesions"

showing 3 items of 3 documents

Automated segmentation of changes in FLAIR-hyperintense white matter lesions in multiple sclerosis on serial magnetic resonance imaging

2019

Longitudinal analysis of white matter lesion changes on serial MRI has become an important parameter to study diseases with white-matter lesions. Here, we build on earlier work on cross-sectional lesion segmentation; we present a fully automatic pipeline for serial analysis of FLAIR-hyperintense white matter lesions. Our algorithm requires three-dimensional gradient echo T1- and FLAIR- weighted images at 3 Tesla as well as available cross-sectional lesion segmentations of both time points. Preprocessing steps include lesion filling and intrasubject registration. For segmentation of lesion changes, initial lesion maps of different time points are fused; herein changes in intensity are analyz…

AdultMaleMultiple SclerosisCognitive Neuroscience610Fluid-attenuated inversion recoverylcsh:Computer applications to medicine. Medical informaticscomputer.software_genrelcsh:RC346-429050105 experimental psychologyCohort StudiesWhite matterLesionYoung Adult03 medical and health sciences0302 clinical medicineSørensen–Dice coefficientVoxelmedicineHumans0501 psychology and cognitive sciencesRadiology Nuclear Medicine and imagingSegmentationLongitudinal Studieslcsh:Neurology. Diseases of the nervous systemmedicine.diagnostic_testbusiness.industry05 social sciencesRegular ArticleMagnetic resonance imagingLesion segmentation; Magnetic resonance imaging; Multiple sclerosis; White matter lesionsMiddle AgedMagnetic Resonance ImagingHyperintensityddc:Cross-Sectional Studiesmedicine.anatomical_structureNeurologylcsh:R858-859.7FemaleNeurology (clinical)medicine.symptombusinessNuclear medicinecomputer030217 neurology & neurosurgeryFollow-Up StudiesNeuroImage: Clinical
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The Presence of White Matter Lesions Is Associated With the Fibrosis Severity of Nonalcoholic Fatty Liver Disease

2016

Abstract We tested whether nonalcoholic fatty liver disease (NAFLD) and/or its histological severity are associated with vascular white matter lesions (WML) in patients with biopsy-proven NAFLD and in non-NAFLD controls. Data were recorded in 79 consecutive biopsy-proven NAFLD, and in 82 controls with normal ALT and no history of chronic liver diseases, without ultrasonographic evidence of steatosis and liver stiffness value  45 years (OR 3.09, 95% CI: 1.06–9.06, P = 0.03; and OR 11.1, 95% CI: 1.14–108.7, P = 0.03), and F2–F4 fibrosis (OR 3.36, 95% CI: 1.29–8.73, P = 0.01; and OR 5.34, 95% CI: 1.40–20.3, P = 0.01) were independently associated with WML (mostly of mild grade) by multivariate…

Liver CirrhosisMalePathologyBiopsySeverity of Illness IndexGastroenterology0302 clinical medicineRisk FactorsNon-alcoholic Fatty Liver DiseaseFibrosisNonalcoholic fatty liver diseaseUltrasonography4500Brain DiseasesSettore MED/12 - Gastroenterologiamedicine.diagnostic_testMedicine (all)Brain DiseaseGeneral MedicineMiddle AgedMagnetic Resonance ImagingWhite MatterFrontal Lobemedicine.anatomical_structureLiverFemale030211 gastroenterology & hepatologyNAFLD liver biopsy fibrosis white matter lesionsResearch ArticleHumanmedicine.medical_specialtyLiver CirrhosiObservational StudySettore MED/08 - Anatomia PatologicaDiagnosis DifferentialWhite matter03 medical and health sciencesInternal medicineBiopsySeverity of illnessmedicineHumansbusiness.industryRisk Factornutritional and metabolic diseasesmedicine.diseasedigestive system diseasesHyperintensityDifferential diagnosisSteatosisSettore MED/36 - Diagnostica Per Immagini E Radioterapiabusiness030217 neurology & neurosurgeryMedicine
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Vascular risk factors, white matter lesions and cognitive impairment in Parkinson’s disease: the PACOS longitudinal study

2020

Abstract Background Vascular risk factors (VRFs) may be associated with cognitive decline in early Parkinson’s disease (PD) but results are inconclusive. The identification of modifiable risk factors is relevant for prevention and treatment. Methods Parkinson’s disease (PD) patients of the PACOS cohort who underwent a baseline and follow-up neuropsychological evaluation were enrolled in the study. PD with Mild Cognitive Impairment (MCI) and dementia (PDD) were diagnosed according to the MDS criteria. A Baseline 1.5 T brain MRI was used to calculate the white matter lesions (WMLs) burden using the Wahlund visual scale. Laboratory data, presence of hypertension, diabetes and use of anti-hyper…

0301 basic medicinemedicine.medical_specialtyEpidemiologyNeuropsychological Testsbehavioral disciplines and activitiesWhite matter lesions03 medical and health sciences0302 clinical medicineInternal medicinemental disordersEpidemiologyHumansMedicineDementiaCognitive DysfunctionLongitudinal StudiesRisk factorCognitive declineOriginal CommunicationFramingham Risk Scorebusiness.industryMild cognitive impairmentParkinson DiseaseEpidemiology Hypertension Mild cognitive impairment Parkinson’s disease Risk factors White matter lesions Humans Longitudinal Studies Neuropsychological Tests Risk Factors Cognitive Dysfunction Parkinson Disease White Mattermedicine.diseaseWhite MatterHyperintensitynervous system diseases030104 developmental biologyBlood pressureRisk factorsNeurologyHypertensionCohortParkinson’s diseaseNeurology (clinical)business030217 neurology & neurosurgeryJournal of Neurology
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